000			01759nam a22002057a 4500
008			231229b ||||| |||| 00| 0 eng d
020			_a9780956478108 (pbk.)
082			_a572.8 _bCRE
100			_aCreighton, Thomas E. _910502
245			_aThe physical and chemical basis of molecular biology
260			_bHelvetian Press _c2010
300			_axxxix, 642p.,
500			_ahttps://www.goodreads.com/book/show/8695767-the-physical-and-chemical-basis-of-molecular-biology
509			_a13
520			_aThe twenty-one chapters of this volume present a comprehensive description of the fundamental physical and chemical phenomena that form the basis of molecular biology. The topics include the fundamental thermodynamic and kinetic properties of biochemical reactions in solution; the physical properties of aqueous solutions, including the hydrophobic effect; both individual and cooperative noncovalent interactions between atoms and molecules; mass spectrometry; and radioactivity. Methods for observing the structures of nucleic acids and proteins, including microscopy, scanning probes, crystallography and NMR, are explained in detail. The interactions of macromolecules with radiation of various types are described in terms of the information that they yield. The hydrodynamic properties of proteins and nucleic acids in aqueous solution and in molecular sieves are described to explain centrifugation and electrophoresis. The interactions of macromolecules with other molecules in solution and when attached to solid supports are described, explaining chromatography, blotting, affinity labeling, and cross-linking.
650			_aMolecular biology _9366
650			_aChemical kinetics _94131
650			_aMass spectrometry _97846
942			_cBK
999			_c9924 _d9924