000			02005nam a22002057a 4500
008			230328b ||||| |||| 00| 0 eng d
020			_a9780878933211 (hb)
082			_a574.875 _bHIL
100			_aHille, Bertil _98435
245			_aIonic channels of excitable membranes
250			_a3nd ed.
260			_aSunderland _bSinauer Associates _c2018
300			_axviii, 814p.
500			_ahttps://global.oup.com/academic/product/ion-channels-of-excitable-membranes-9780878933211?cc=in&lang=en&#
520			_aIon channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists."
650			_aNeurons _96850
650			_aIon channels _98436
650			_aExcitable membranes _98437
942			_cBK
999			_c8400 _d8400